EyeScience® Macular Health Formula™ – Auto Delivery2020-04-15T15:21:53-04:00

EyeScience® Macular Health Formula – Auto Delivery, Save 10% + FREE Shipping!

$29.65 / month

The most complete eye vitamin

Developed by leading ophthalmologists and decades of research, our Macular Health Formula™ is one of the most complete nutritional supplements for eye health available today.

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AREDS is a Landmark Research Project that Evaluated
the Natural History of AMD and Cataract

It featured a controlled, randomized clinical trial that evaluated the effect of pharmacological doses of nutritional supplements on the rate of progression to advanced AMD.1

The researchers evaluated the protective effects of zinc and/or a formulation that consisted of nutrients with antioxidant properties, including vitamin Cvitamin E and beta-carotene. The researchers concluded that a combination of these antioxidants with zinc led to an overall 25% risk reduction in disease progression in individuals who had a moderate risk of AMD development.1 The overall risk of moderate vision loss was reduced by 19% at five years.1

However, like many other groundbreaking studies, the original AREDS researchers generated numerous unanswered questions and suggestions for areas of further study. Many of these items have already been or will be addressed by AREDS2. The enrollment for AREDS2 concluded in June 2008, and participants will be followed for five to six years. The first official reports from AREDS2 are anticipated in 2013.2

The primary objective of AREDS2 is to evaluate the effect of dietary carotenoids—including lutein and zeaxanthin—and/or omega-3 fatty acids—including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)—on the progression to advanced AMD.3

In an ideal world of healthy living, these dietary compounds would be best obtained through a balanced diet. In reality, however, our food intake is severely deficient of these important nutrients.

The average western diets contain 1.3mg to 3mg of lutein and zeaxanthin, with a ratio of lutein to zeaxanthin of 7:1.4,5 The highest natural concentrations of lutein are found in dark green leafy vegetables, such as spinach, kale and collard greens, whereas zeaxanthin is the major carotenoid found in corn, orange peppers and oranges.

Additionally, both lutein and zeaxanthin are found in a high-mole percentage in egg yolk.6 It is important to note that approximately 78% of dietary lutein and zeaxanthin is sourced from vegetables.6

Of the numerous carotenoids found in nature, just luteinzeaxanthin and meso-zeaxanthin are present in human macular pigment.8 Because these carotenoids are likely to play a part in the maintenance of normal cell physiology, the absence or reduced bioavailability of either one may account for the development of the structural changes that occur in patients with AMD.

Both lutein and zeaxanthin were considered for study in AREDS; however, neither carotenoid was commercially available for manufacturing in a research formulation.3 However, AREDS2 researchers are studying their efficacy in preventing the progression of macular degeneration in subjects who present with intermediate drusen.

AMD is a major cause of blindness among individuals with European ancestry and accounts for more than 50% of all blinding conditions.10

The Eye Disease Prevalence Research Group estimates that 1.2 million U.S. residents are living with neovascular AMD and 970,000 have geographic atrophy; these numbers expected to rise 50% by the year 2024.10

There are three major purported risk factors for AMD: age, positive family history and smoking. In fact, smoking is the only consistently proven risk factor for AMD.11-14 As with other age-related diseases, the free radical theory of aging has been proposed as an underlying cause of AMD. This theory proposes that oxidative stress occurs in the retina because levels of reactive oxidative intermediates (ROIs) increase to a level that exceeds the detoxifying capacity of antioxidants.

We have now learned that diets rich in lutein and zeaxanthin have been shown to protect against the development of AMD.21-24 Oral supplementation of lutein or lutein/zeaxanthin combinations in individuals at risk for AMD development and control subjects increased mean serum levels of the carotenoid metabolites that constitute the macular pigment. These effects are not always uniform in all individuals.25-29

Omega-3 Long Chain Polyunsaturated Fatty Acids

One important question being addressed by AREDS2 is whether high supplemental doses of omega-3 fatty acids will inhibit the development of advanced AMD. Researchers have previously determined that DHA and EPA may serve as cytoprotective agents against several retinal diseases as well as cataracts.30 DHA is a major component of retinal photoreceptor outer segment membranes, and an insufficiency of this essential fatty acid can result in altered retinal function.31-35

Overall, epidemiological studies have shown a higher prevalence of AMD in individuals with diets high in total fat intake (exempting diets that are specifically high in omega-3 fatty acids).36-43


Another important supplement investigated in AREDS was zinc. The tolerable upper level of daily zinc intake is 40mg; however, AREDS researchers  supplemented patients with 80mg of zinc per day.44,45 AREDS2 investigators are examining the effects of both 80mg and 40mg dosages of zinc per day to determine whether a lower dose could still prevent the development or progression of AMD.


AREDS2 will also investigate the effect of eliminating beta-carotene from the original AREDS formulation. This is of particular interest because high doses of beta carotene alone, or in combination with vitamin E, are associated with a statistically significant risk of developing lung cancer in smokers.48,49 Therefore, it is not recommended to place any patients who smoke or recently quit smoking on beta carotene supplementation.

The Million-dollar Question

Have we now officially determined that dietary and lifestyle changes at an early age can reduce the risk for AMD development and progression?

The answer is quite clear: Yes.

Results from AREDS and other nutritional studies strongly indicated that the earlier an individual begins to make lifestyle alterations and take nutritional supplements, the less risk he or she has for degenerative eye disease. And, for older patients who may already be at an increased risk for AMD, it is better late than never when it comes to the use of nutraceuticals.

In the very near future, the results from AREDS2 will shed more light on the most effective management options for AMD as well as address which specific nutritional supplements are most useful in disease prevention and treatment

Beyond AREDS2:

EyeScience Macular Health Formula was designed to take the best of both AREDS and AREDS 2.  Together with additional clinically proven nutrients, our formula is the most complete ocular supplement designed for those with and without AMD.

ProductEyeScience® Macular Health Formula Bausch+Lomb® Ocuvite® Adult 50+Bausch+Lomb® PreserVision® AREDS 2 Formula
ManufacturerEyeScience LabsBausch & LombBausch & Lomb
Daily Dosage2 capsules / day1 softgel / day2 softgels / day
Vitamin C500mg150mg500mg
Vitamin E400 I.U.20mg400 I.U.
Vitamin B-620mg
Bilberry 25%15mg
Alpha-Lipoic Acid20mg
Grapeseed Extract20mg
MacuGlo™ Proprietary Blend (Eyebright herb + AstaReal® Astaxanthin12mg
NotesPhysician Formulated with AREDS 2 ingredients and goes beyond with Powerful AntioxidantsIncludes 250mg Omega-3 Fatty Acids
What Is The Macula?2019-11-26T19:50:08-05:00

The human eye is similar to a camera, the retina of the eye is the film of a camera that takes the picture and stores the image. The macula at the back of the eye functions like a lens. It is the part of the eye that allows us to see fine details such as the numbers on a watch, the features on someone’s face, or the amount of spices poured from a container.

Why is it difficult to maintain ideal macular health?2019-11-26T19:46:51-05:00

There are a number of reasonss: more ultraviolet light in our environment due to a thinning ozone layer, people living longer, environmental pollutants, smoking, poor diet, overweight, etc.” Another factor may be our aging population, people are living longer than ever and we are seeing new health concerns because of it.

What should I eat to maintain optimal ocular health?2019-11-26T19:42:39-05:00

Several research studies have proven that diets rich in carotenoids, antioxidant vitamins such as C and E, and omega-3 fatty acids, can improve eye health or slow down the progression of common eye conditions that lead to vision loss.

Carotenoids are compounds that are found in plants, which have been associated with maintenance of not only healthy macula, but also the health of many of the body’s systems. Dark green, yellow and orange fruits and vegetables, especially those high in the carotenoids known as lutein and zeaxanthin, appear to be the most useful nutritional factors in maintaining healthy macula. Lutein and zeaxanthin are the primary pigments in the macula and are thought to protect the retina from ultraviolet light.

Lutein is found in spinach, collard greens, kale, broccoli, papaya, oranges, kiwi, mango, green beans, peaches, sweet potatoes, lima beans, squash, red grapes, and green bell pepper. Yellow corn, honeydew melon, squash, oranges, mango, kale, apricots, peaches, and orange bell pepper are good sources of zeaxanthin.

Foods abundant in vitamin C include green peppers, citrus fruits, tomatoes, broccoli, strawberries, sweet and white potatoes, leafy greens, and cantaloupe. Vitamin E is found in eggs, fortified cereals, fruit, wheat germ, green leafy vegetables, nuts/nut oils, vegetable oils, and whole grains. Wild salmon, sardines, walnuts, and flaxseed oil are good sources of omega-3 fatty acids.

Can my lifestyle make a difference?2019-11-26T19:41:52-05:00

Your lifestyle can play a role in promoting your macular health.

– Eat a healthy diet high in green leafy vegetables and fish.
– Don’t smoke.
– Maintain normal blood pressure.
– Watch your weight.
– Exercise.

What is EyeScience® Macular Health Formula?2019-11-26T19:41:30-05:00

EyeScience® Macular Health Formula is the most complete ocular supplement on the market. It was created by a leading retina and macular specialist and based on two decades of published research. It contains 14 clinically proven nutrients including those found in the AREDS formula. Its unique and cutting edge blend of vitamins, herbal extracts, amino acids and antioxidants help give your eyes the nutrients they need to stay healthy and keep you seeing into the future.

What did the clinical research named AREDS indicate?2019-06-12T22:48:23-04:00

Patients and their doctors have often wondered if taking vitamin supplements could help towards health maintenance in several areas, including eye health. Many small studies have suggested a link between vitamin supplementation and the continuation of optimal eye health. Unfortunately, many of these studies were not complete enough to answer some important questions.

Recently, the National Institute of Health completed a major study to address the questions of vitamins vs. macular health. AREDS was a study that followed the macular health of 3,600 individuals at 11 centers around the country over five years. Overall, it found that many individuals had superior macular health from taking certain anti-oxidant and zinc supplementation. Moreover, the safety of these supplements was carefully followed. These vitamins have become known as the “AREDS Formulation”.

Who should take the AREDS Formulation?2019-06-12T22:48:43-04:00

Your eye doctor will be able to tell by examining your retina who will benefit most from it. Your eyes will need to be dilated in order to make this determination.

What are the dosages of vitamins in the AREDS Formulation?2019-06-12T22:49:01-04:00

The specific amounts studied were: 500mg of Vitamin C, 400IU of Vitamin E, 15mg of Beta-Carotene (often labeled as 25,000 IU of Vitamin A), 80mg of Zinc as Zinc Oxide, 2mg of Copper as cupric oxide. Copper was added to help prevent copper deficiency anemia as a result of high zinc intake.

Are there any side-effects from taking the AREDS Formulation?2019-11-26T20:37:37-05:00

Overall, there were no major side-effects noted. Some patients taking the supplements had minor side-effects including urinary tract problems secondary to the zinc. Others noted mild yellowing of the skin secondary to the beta-carotene.

Does EyeScience® Macular Health Formula contain the vitamins and minerals in the proper doses recommended by AREDS?2019-11-26T20:28:44-05:00

Our formula goes well beyond AREDS. We have included 14 clinically proven nutrients including Lutien, Zeazanthin, Bilberry, and Omega 3. Our formula does not have Betacarotene like the AREDS formula. There is growing evidence that betacartone taken in a pill form does not provide a benefit to the eyes and can be dangerous for those who previously smoked or continue to use cigarettes.

Is it dangerous for current or former smokers to take the AREDS Formulation?2019-11-26T20:28:12-05:00

EyeScience® Macular Health Formula is safe for smokers. Large clinical trials have demonstrated that beta-carotene increases the risk of lung cancer in current smokers. These patients should avoid taking the beta-carotene found in the AREDS Formulation. There is no direct evidence that former smokers are at risk from beta-carotene, but given that patients still have a heightened risk of lung cancer beyond the time they quit smoking, it would be reasonable for these patients to avoid high dose beta-carotene as well.

What is Lutein?2019-11-26T20:27:19-05:00

Lutein is a potent antioxidant carotenoid found in abundance in fruits and green leafy vegetables. Lutein is also one of the dominant pigments found in the macular region of the healthy retina, because of this many eye doctors recommend Lutein to their patients for macular health support.

Why wasn’t Lutein included in the AREDS?2019-11-26T20:26:54-05:00

Lutein was not available when AREDS was started.

What are the advantages of EyeScience® Macular Health Formula over competing products?2019-11-26T20:26:40-05:00

Research has proven that the ingredients in EyeScience® Macular Health Formula not only support long-term macular health, but also help improve visual function overall. This exclusive nutritional formula is based on two decades of national and international macular research, and contains the most complete formula of nutrients in the precise concentrations most beneficial to your macula.

Does EyeScience® Macular Health Formula contain any preservatives or artificial ingredients?2019-11-26T20:24:12-05:00

Our product is made from natural ingredients and contains no starches or sugars, yeast, or artificial colors or flavors. It is gluten free.

Can I take my regular multivitamin with EyeScience® Macular Health Formula?2019-06-12T22:51:29-04:00

Yes, The EyeScience® formulation is not a substitute for your daily multi-vitamin or other supplements you may be taking such as calcium or Vitamin D for bone health. However, do not take additional supplements that are already included in the EyeScience® formulation.

Complete nutrition for healthy vision

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