The science of eye health ingredients

The science of eye health ingredients

By Stephen Daniells, 13-Jul-2010

Related topics: Research, Antioxidants, carotenoids, Minerals, Nutritional lipids and oils, Vitamins & premixes, Eye health

In the second part of our special series on eye health, NutraIngredients takes a closer look at the science behind lutein, omega-3 and the other ingredients eyeing a place on the podium for eye health.

The health condition garnering most of the attention in the eye health segment is age-related macular degeneration, or AMD. As the name suggests, this is a degenerative retinal disease that causes central vision loss and leaves only peripheral vision.

Despite the fact that approximately 25 to 30 million people worldwide are affected by AMD, awareness of the condition is low, says AMD Alliance International. And as the generation of Baby Boomers gets older, the Alliance expects incidence to be on the rise and triple by 2025.

The macula is a yellow spot of about five millimeters diameter on the retina. As we age, levels of the pigments in the macula decrease naturally, thereby increasing the risk of AMD. The yellow color is due to the content of the carotenoids lutein and zeaxanthin, which we derive from the diet.

These compounds are the only carotenoids capable of filtering the harmful blue light than can damage cells in the eye, the rods and the cones, explains Holger Becker, PhD, Xangold Global Product Manager at Cognis.

A thin macular pigment can allow the blue light through and destroy the cells. Maintaining high levels of both carotenoids, and therefore the macular pigment, is a valid approach to maintaining eye health and reducing the risk of AMD, adds Becker.

Scientific advances

In 1994, Dr Johanna Seddon and her co-workers at Harvard University reported a link between the intake of carotenoid-rich food, particularly dark green leafy vegetables like spinach, and a significant reduction in AMD.

“Although these observational nutritional data do not establish causality, it seems prudent to concur with the recommendation of increasing the consumption of vegetables in the diet and, in particular, to include dark green, leafy vegetables that are rich in lutein and zeaxanthin,” concluded the researchers in the Journal of the American Medical Association (Vol. 272, pp. 1413-1420).

Since then scores of studies have come out supporting the benefits, and elucidating the mechanisms involved. Commenting on the strength of the lutein-AMD science, Dr Diane Alexander, technical service manager, R&D for Kemin Health said: "I think the science is conclusive. There is a lot of epidemiological evidence, as well as many supplementation studies, which show that increased serum levels of lutein and zeaxanthin are associated with increased macular pigmentation."

Dr Alexander pointed to a recent review by five experts that concluded that macular pigment optical density (MPOD) - an indicator of xanthophyll levels in the eye - may also "potentially serve as a biomarker not only for predicting the risk for eye disease but also for visual function" (Vision Research, 2010, Vol. 50, pp 716–728).

Ratios of lutein to zeaxanthin are important, said Abhijit Bhattacharya from OmniActive Health Technologies. “When you look at data of levels in healthy diets – based on serum concentrations we typically need 5:1 lutein to zeaxanthin,” he said. “So we probably need to be supplementing at this 5:1 ratio.”

Final support for the link may be a few years away if the high profile AREDS2 (Age-Related Eye Disease Study) reports positive results. The intervention, expected to end in 2013, is using a formulation which includes lutein and zeaxanthin, and the omega-3 fatty acids DHA and EPA. The nutrients for the new study are supplied by DSM Nutritional Products using Kemin’s FloraGlo lutein ingredient.

Another carotenoid, astaxanthin, has also been linked to eye health. A patent by the University of Illinois’ Mark Tso in 1996 reports a method “to prevent, retard or treat eye and central nervous system diseases or injuries, such as age-related macular degeneration” using astaxanthin (US Patent #5527533).

Health claims

While the science appears substantial, the European Food Safety Authority’s (EFSA) Panel on Dietetic Products, Nutrition and Allergies (NDA) is not yet convinced. The NDA’s lutein opinion found that while the carotenoid had the ability to raise macular pigment density, this effect did not necessarily benefit, “maintenance of normal vision”. A similar response was issued for meso-zeaxanthin.

Lutein producers are not accepting the decision lightly and there is some collaboration to ensure future health claims success. NutraIngredients will cover the regulatory aspects of eye health in the fourth parts of its series.

Looking to fish oil

Beyond lutein and zeaxanthin, a growing body of science supports potential benefits for omega-3 fatty acids in AMD. The mechanism behind omega-3's putative effect was proposed by researchers from the University of Sydney to be down to insufficient fatty acid intake causing abnormal metabolism in the retina, which affects cell renewal (Archives of Opthamology, Vol. 124, pp 981-986).

 

Furthermore, a meta-analysis by Australian scientists reported that a high intake of omega-3 fatty acids and fish may reduce the risk of AMD by up to 38 per cent (Archives of Ophthalmology, 2008, Vol. 126, pp. 826-833).

This was followed by a study published in the American Journal of Clinical Nutrition (2009, Vol. 90, pp. 1601-1607), which found that increased intakes of omega-3 fatty acids may reduce the risk of developing age-related blindness by 30 percent. The results were derived from a sub-section of 1,837 people participating in AREDS. All the participants were considered to be at a moderate-to-high risk of advanced AMD.

Vision loss beyond AMD

Eye health is not all about AMD, however. The benefits of lutein may also extend to rentinitis pigmentosa – a group of inherited eye diseases that affect the retina. It causes the degeneration of photoreceptor cells in the retina, bringing progressive vision loss to about one in 4,000 people worldwide.

A study published in the Archives of Ophthalmology, found that a combined supplement of lutein and vitamin A may slow vision loss associated with these diseases. A daily supplement containing 12 milligrams of lutein in combination with 15,000 International Units of vitamin A (retinyl palmitate) was associated with a preservation of mid-peripheral vision.

There is also significant evidence for the benefits of lutein and zeaxanthin for cataracts and cataract-related conditions, said OmniActive’s Bhattacharya.

This makes sense, said Kemin’s Alexander since lutein is present in the lens of the eye, and cataracts are caused in part by oxidation of the lens.

Healthy eyes in healthy people

Beyond AMD, there is also data that lutein may also protect against the detrimental effects of long-term computer display light exposure, according to a Chinese study published in the British Journal of Nutrition (2009, Vol. 10, pp 186-190).

“Visual function in healthy subjects who received the lutein supplement improved, especially in contrast sensitivity, suggesting that a higher intake of lutein may have beneficial effects on the visual performance,” wrote the researchers from Peking University.

Another study with subjects aged between 22 and 45 found that a combination of lutein, zeaxanthin and blackcurrant extract may reverse signs of visual fatigue. Researchers from Japan and Singapore reported that visual fatigue, caused by many factors, not least staring at computer monitors for long hours, may be eased a daily supplement containing blackcurrant fruit extract (200 mg), lutein (5 mg), and zeaxanthin (1 mg) (Applied Ergonomics, 2009, Vol. 40, pp. 1047-1054).

Furthermore, a study published in the journal Optometry and Vision Science (2008, Vol. 85, pp. 82-88) reported that lutein and zeaxanthin may reduce the deleterious effects of glare on a test group of people with normal eyesight.

Researchers from the University of Georgia, Athens recruited 40 healthy subjects with an average age of 23.9 and assigned them to receive daily supplements of lutein (10 mg, FloraGlo, Kemin) and zeaxanthin (2 mg, OptiSharp, Kemin) for six months.

"The positioning of lutein is changing," said Kemin’s Dr Alexander. "[These new studies show] it is an essential nutrient that everyone needs everyday to protect their vision."

Dry eyes

Another area not to be over-looked in eye health is dry eyes. Keratoconjunctivitis sicca, or dry eye syndrome, is a condition where the eyes do not make enough tears, or the tears evaporate too quickly. This produces dry eyes and increases the risk of inflammation. According to a recent study by Finnish researchers, the prevalence of dry eye can be up to 30 per cent in people aged 50 y and older.

Fatty acids are again linked to a potential benefit, and the omega-3 and omega-6 content of sea buckthorn was recently touted as the main bioactives behind sea buckthorn’s ability to potentially reduce symptoms of dry eye syndrome.

Scientists from the University of Turku reported in the Journal of Nutrition (doi: 10.3945/jn.109.118901) that the linolenic acid contained in the oil is a basis for anti-inflammatory compounds, which could reduce inflammation. The researchers also note that sea buckthorn oil is a rich source of vitamin E and that antioxidants “may protect the eye from oxidative damage leading to activation of inflammatory cascades”.

NutraIngredients’ series will continue with the next section looking at the supply of eye health ingredients.

 

Resveratrol may boost eye health: Study

Resveratrol may boost eye health: Study

1 commentBy Stephen Daniells, 28-Jun-2010

Related topics: Research, Antioxidants, carotenoids, Phytochemicals, plant extracts, Cardiovascular health, Eye health

The vascular benefits of resveratrol – a compound found in red wine, blueberries and peanuts – may extend to reducing the risk of blindness for diabetics and seniors, says a new study.

According to findings published in the American Journal of Pathology, resveratrol could reverse the abnormal formation of blood vessels in the retina of mice subjected to a laser treatment.

Scientists from Washington University School of Medicine in St. Louis identified a pathway called the eukaryotic elongation factor-2 kinase (eEF2) regulated pathway, which they proposed as being responsible for the compound's protective effects.

"We have identified a novel pathway,” said lead researcher, Rajendra Apte, MD, PhD. "And we believe the pathway may be involved both in age-related eye disease and in other diseases where angiogenesis plays a destructive role."

Apte and his co-workers note that this was a surprise the anti-ageing potential of resveratrol was proposed to occur via a different pathway.

“A great deal of research has identified resveratrol as an anti-aging compound, and given our interest in age-related eye disease, we wanted to find out whether there was a link,” said Apte. “There were reports on resveratrol's effects on blood vessels in other parts of the body, but there was no evidence that it had any effects within the eye,” he added.

The promise of long life

Resveratrol, a powerful polyphenol and anti-fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so-called 'French Paradox'. The phrase, coined in 1992 by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and levels of wine consumption.

Interest in the compound exploded in 2003 when research from David Sinclair and his team from Harvard reported that resveratrol was able to increase the lifespan of yeast cells. The research, published in Nature, was greeted with international media fanfare and ignited flames of hope for an anti-ageing pill.

According to Sinclair’s findings, resveratrol could activate a gene called sirtuin1 (Sirt1 – the yeast equivalent was Sir2), which is also activated during calorie restriction in various species, including monkeys.

 
Since then studies in nematode worms, fruit flies, fish, and mice have linked resveratrol to longer lives. Other studies with only resveratrol have reported anti-cancer effects, anti-inflammatory effects, cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimer’s.

Study details

The new study linked resveratrol was not related to sirtuins, however, said the researchers. For their study that exposed mouse retinas to a laser treatment that initiated blood vessel formation, or angiogenesis. When resveratrol was fed to the mice, however, the researchers observed that angiogenesis was inhibited and that abnormal blood vessels were eliminated.

The effects were identified as occurring via the eEF2 pathway.

Apte stressed that the animal model of macular degeneration they used is not the same as the human version of the disease, Furthermore, the mice received large resveratrol doses, he said, much more than would be found in several bottles of red wine. If resveratrol is to be effective in people, said Apte, it would need to be given in pill form because of the high doses required.

Eyes on the potential

The researchers note that the findings could have potential for both age-related macular degeneration (AMD) and diabetic retinopathy. AMD is a degenerative retinal disease that causes central vision loss and leaves only peripheral vision, and the leading cause of legal blindness for people over 55 years of age in the Western world, according to AMD Alliance International.

According to the National Institute of Health, between 40 and 45 percent of Americans diagnosed with diabetes already have some stage of diabetic retinopathy, a major cause of blindness in people with diabetes and is one of the most feared diabetic complications.

Source: American Journal of Pathology
July 2010, Volume 177, Pages 481-492, doi: 10.2353/ajpath.2010.090836
“Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway”
Authors: A.A. Khan, D.S. Dace, A.G. Ryazanov, J. Kelly, R.S. Apte

 

Study: Many Sunscreens May Be Accelerating Cancer

Aol News05/28/10
WASHINGTON (May 24) -- Almost half of the 500 most popular sunscreen products may actually increase the speed at which malignant cells develop and spread skin cancer because they contain vitamin A or its derivatives, according to an evaluation of those products released today.

AOL News also has learned through documents and interviews that the Food and Drug Administration has known of the potential danger for as long as a decade without alerting the public, which the FDA denies.

The study was released with Memorial Day weekend approaching. Store shelves throughout the country are already crammed with tubes, jars, bottles and spray cans of sunscreen.

The white goop, creams and ointments might prevent sunburn. But don't count on them to keep the ultraviolet light from destroying your skin cells and causing tumors and lesions, according to researchers at Environmental Working Group.

In their annual report to consumers on sunscreen, they say that only 39 of the 500 products they examined were considered safe and effective to use.

The report cites these problems with bogus sun protection factor (SPF) numbers:
  • The use of the hormone-disrupting chemical oxybenzone, which penetrates the skin and enters the bloodstream.
  • Overstated claims about performance.
  • The lack of needed regulations and oversight by the Food and Drug Administration.

But the most alarming disclosure in this year's report is the finding that vitamin A and its derivatives, retinol and retinyl palmitate, may speed up the cancer that sunscreen is used to prevent.
Chart showing relationship between Vitamin A and tumors.
Environmental Working Group
 

A dangerous additive

The industry includes vitamin A in its sunscreen formulations because it is an anti-oxidant that slows skin aging.

But the EWG researchers found the initial findings of an FDA study of vitamin A's photocarcinogenic properties, meaning the possibility that it results in cancerous tumors when used on skin exposed to sunlight.

"In that yearlong study, tumors and lesions developed up to 21 percent faster in lab animals coated in a vitamin A-laced cream than animals treated with a vitamin-free cream," the report said.

The conclusion came from EWG's analysis of initial findings released last fall by the FDA and the National Toxicology Program, the federal government's principle evaluator of substances that raise public health concerns.

EWG's conclusions were subsequently scrutinized by outside toxicologists.

Based on the strength of the findings by FDA's own scientists, many in the public health community say they can't believe nor understand why the agency hasn't already notified the public of the possible danger.

"There was enough evidence 10 years ago for FDA to caution consumers against the use of vitamin A in sunscreens," Jane Houlihan, EWG's senior vice president for research, told AOL News.

"FDA launched this one-year study, completed their research and now 10 years later, they say nothing about it, just silence."

On Friday, the FDA said the allegations are not true.

"We have thoroughly checked and are not aware of any studies," an FDA spokesperson told AOL News. She said she checked with bosses throughout the agency and found no one who knew of the vitamin A sunscreen research being done by or on behalf of the agency.

But documents from the FDA and the National Toxicology Program showed that the agency had done the research.

"Retinyl palmitate was selected by (FDA's) Center for Food Safety and Applied Nutrition for photo-toxicity and photocarcinogenicity testing based on the increasingly widespread use of this compound in cosmetic retail products for use on sun-exposed skin," said an October 2000 report by the National Toxicology Program.

FDA's own website said the animal studies were done at its National Center for Toxicological Research in Jefferson, Ark. And it was scientists from the FDA center and National Toxicology Program who posted the study data last fall.

In a perfect world

The ideal sunscreen would completely block the UV rays that cause sunburn, immune suppression and damaging free radicals. It would remain effective on the skin for several hours and not form harmful ingredients when degraded by UV light, the report said.
Graph of melanoma of the skin rates from 1975 to 2006.
National Cancer Institute
Graph of melanoma of the skin rates from 1975 to 2006. APC stands for annual percent change and AAPC stands for average annual percent change.

But in the U.S., there is currently no sunscreen that meets all of these criteria. European countries have more chemical combinations to offer, but in the U.S. the major choice is between the "chemical" sunscreens, which have inferior stability, penetrate the skin and may disrupt the body's hormone systems, and "mineral" sunscreens zinc and titanium dioxide.

Increasingly, as AOL News reported in March, the industry is using titanium dioxide that is made nanosized, which a growing number of researchers believe have serious health implications.

The sunscreen industry cringes when EWG releases its yearly report -- this is its fourth. The industry charges that the advocacy group wants to do away with all sunscreen products, a claim that is not accurate.

The report's researchers clearly say that an effective sunscreen prevents more damage than it causes, but it wants consumers to have accurate information on the limitations of what they buy and on the potentially harmful chemicals in some of those products.

EWG does warn consumers not to depend on any sunscreen for primary protection from the sun's harmful ultraviolet rays. Hats, clothing and shade are still the most reliable sun protection available, they say.

Don't count on the numbers

Some of us are old enough to remember when the idea of having a tan was good, a sign of health, when billboards and magazine ads featured the Coppertone girl showing off her tan when a puppy pulls down her bathing suit bottom.

Going for that tan, we coated our kids and ourselves with sun blockers with sun protection factors of 1 or 2. Some overly cautious parents might have smeared on a 4 during the hottest part of a day.

But we've learned of the dangers that come from exposure to the sun's rays, especially ultraviolet A and B. So today, drugstore shelves are crammed with sunscreens boasting SPFs of 30, 45, 80 or even higher.

However, the new report says those numbers are often meaningless and dangerous because products with high SPF ratings sell a false sense of security, encouraging people using them to stay out in the sun longer.

"People don't get the high SPF they pay for," the report says. "People apply about a quarter of the recommended amount. So in everyday practice, a product labeled SPF 100 really performs like SPF 3.2, an SPF 30 rating equates to a 2.3 and an SPF 15 translates to 2."

In 2007, the report says, the FDA published proposed regulations that would prohibit manufacturers from labeling sunscreens with an SPF higher than "SPF 50." The agency wrote that higher values would be "inherently misleading," given that "there is no assurance that the specific values themselves are in fact truthful."

This is being widely ignored by the sunscreen makers who are heavily advertising their 80, 90 and 100 SPF products.

"Flouting FDA's proposed regulation," companies substantially increased their high-SPF offerings in 2010 with one in six brands now listing SPF values higher than 50. "Neutrogena and Banana Boat stand out among the offenders, with six and four products labeled as 'SPF 100,' respectively," the new report says.

The full list of the best and worst sunscreens can be found on the EWG's searchable database. (Update: The database has been loading slowly today. You may want to try it again later.)
Filed under: Nation, Health, Top Stories

Omega-3 Influences Weight Management.

nhiondemand.com04/08/10
Omega-3 Influences Weight Management.
Date: 4/7/2010
Source: Lipids

 

Everyone knows what it means to be overweight. From early age on, children can tell the difference between "fat" and "thin" people. They also get the clear message that fat people are apt to be less popular. Body weight is one of the most basic issues of human life. Self-esteem, acceptance among peers and perhaps lifelong success or failure are all tied to our physical appearance. Medically speaking, not all overweight people are obese. Obesity is defined as weight that exceeds 15 percent of normal weight for height and body type. "Morbid" obesity exceeds 20 percent of optimum weight. An obese or overweight person is at high risk for a number of serious health problems, including heart disease, high blood pressure, stroke, varicose veins, dementia, psychological stress, depression, osteoarthritis, high cholesterol, and diabetes.

Omega-3 refers to a group or "family" of unsaturated fatty acids. The first fatty acid in this group is named alpha linolenic acid or just linolenic acid, and sometimes it is just called omega-3. Linolenic acid cannot be made in the body and therefore, it is classified as an essential fatty acid and must be obtained from either the diet or in supplement form. The other two fatty acids in the omega-3 family are named eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The body can manufacture EPA and DHA by conversions from linolenic acid. Flaxseed, chia, rapeseed, soybeans, alfalfa, and walnuts contain omega-3 fatty acids. Cold water fish and wild game also are sources of omega-3 fatty acids.

Researchers published a study in the journal Lipids investigating whether omega-3 had any influence on weight management. The double-blind trial involved 160 overweight volunteers (body mass index, BMI >30) for 90 days. The experimental group was given food high in animal fat with low PUFA/saturated fatty acid but a low omega-6/omega-3 ratio using linseed-fed animals. The control group was provided with food containing less animal fat, higher PUFA/saturated fatty acid and higher omega-6/omega-3 ratio. The results were a significant reduction in weight, BMI and hip circumference within both groups. However, 150 days after the end of the trial the researchers found a significant weight gain in the control group while the experimental group experienced no significant weight gain indicating a diet rich in omega-3 obtained by eating linseed-fed animals may indeed be effective in weight management and was also effective in maintaining EPA and DHA levels without fish consumption.1

1 Legrand P, Schmitt B, Mourot J, et al. The consumption of food products from linseed-fed animals maintains erythrocyte omega-3 fatty acids in obese humans. Lipids. 2010;45(1):11-9.

 

Flaxseed Lowers High Cholesterol in Men, Study Suggests

ScienceDaily (Mar. 30, 2010) — A new study from Iowa State University's Nutrition and Wellness Research Center (NWRC) may give men a way to combat high cholesterol without drugs -- if they don't mind sprinkling some flaxseed into their daily diet.


 
Suzanne Hendrich, an ISU professor in food science and human nutrition, led a study that examined the effects of flaxseed lignan in 90 people diagnosed with high cholesterol. The results showed that consuming at least 150 milligrams of flaxseed lignans per day (about three tablespoons) decreased cholesterol in men, but not women, by just under 10 percent over the three months that they were given the flaxseed.

While Hendrich admits that's considerably less than the expected outcome from cholesterol-lowering drugs -- approximately 10 to20 percent for three months, depending on the individual -- it's still enough to make flaxseed a more natural option for some men.

"Because there are people who can't take something like Lipitor, this could at least give you some of that cholesterol-lowering benefit," Hendrich said. "The other thing is, there are certainly some people who would prefer to not use a drug, but rather use foods to try to maintain their health. So this potentially would be something to consider."

Americans suffer from high blood cholesterol

According to the Centers for Disease Control and Prevention, about 17 percent of Americans suffer from high blood cholesterol -- a fat-like substance found in the body that can clog arteries and contribute to heart disease.

Hendrich developed the study with ISU master's student Kai Ling Kong and doctoral graduates Zhong Ye, Xianai Wu, and Sun-Ok Lee to determine whether the main lignan in flaxseed, secoisolariciresinol diglucoside, could lower cholesterol. They'll be presenting results of the research at the American Society for Nutrition's annual meeting at Experimental Biology 2010, April 24-28, in Anaheim, Calif.

The study's 90 subjects -- which included twice as many men as women -- all had high cholesterol, but no other underlying health conditions. The participants were divided into three groups and were randomly assigned to daily consume tablets that contained zero, 150, or 300 milligrams of flaxseed lignans for 12 weeks.

It's the flaxseed lignans -- a group of chemical compounds found in plants that are known for their protective health effects -- that may help lower cholesterol, according to Hendrich. These compounds are converted to their bioactive forms by gut microbes. Hendrich reports that they made a healthy conversion in the subjects in this study, with no adverse health consequences.

No cholesterol-lowering effect in women

While the study found that the flaxseed lignans lowered cholesterol in men, it did not produce a significant change in women.

"We're really puzzled about that because we were looking at post menopausal women and these lignans are known as plant estrogens, so they have a very weak but measurable estrogen effect," Hendrich said. "So potentially, they would have a mild effect for substituting some estrogens in women. It's really hard to know why [there was no effect in women] and whether these substances are counteracting, possibly, some testosterone in men, which of course women don't have. It's definitely something we'd like to investigate further."

Hendrich reports the flaxseed lignan tablets used in this study are not currently available in the U.S. to her knowledge. In the absence of tablets, she says flaxseed can also be sprinkled on cereal, or added in a muffin mix or bread, although whole seeds are not very digestible. Ground flaxseed meal can also provide the desired cholesterol-lowering lignans, according to Hendrich, but it will oxidize over time and could potentially affect the flavor of the foods that it's in. She points out that the oxidation of the product also would diminish the flaxseed's omega-3 fatty acids, which can prevent heart attacks, so freshness is important in the product's impact.

The ISU researcher hopes to publish the study in a professional journal. She also plans further investigation on whether flaxseed can be taken in combination with other known cholesterol-lowering substances, and whether it could prevent high cholesterol in the first place.

The $190,000 research study was jointly funded by the Archer Daniels Midland Company and Grow Iowa Values Fund.

Study Supports Potential Eye Health Benefits of Bilberry Extracts

NutraIngredients.com03/25/10

Study supports potential eye health benefits of bilberry extracts

25-Mar-2010

Related topics: Research

Extracts from bilberry may improve symptoms of inflammation in the eye, says a new study with mice that builds the eye health benefits of the ingredient.

Chinese scientists report in the Journal of Agricultural and Food Chemistry that doses of a bilberry extract increased antioxidant activity of the blood, which was accompanied by improvements in blood levels of vitamin C and antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx).

The researchers noted that the bilberry extract used in the study – Indena’s branded Mirtoselect ingredient – could protect against endotoxin-induced uveitis (EIU), an animal model of inflammation in the eye.

Source: Journal of Agricultural and Food Chemistry
Published online ahead of print, doi:10.1021/jf904572a
"Protective Effects of Bilberry (Vaccinium myrtillus L.) Extract against Endotoxin-Induced Uveitis in Mice"
Authors: N. Yao, F. Lan, R.-R. He, H. Kurihara